Center for Genome Sciences & Systems Biology (CGS_SB)


Addressing health and human disease

The CGS_SB is studying the role of genes in human health, including the influence of the millions of microbes that live in and on humans. The center also fosters development and application of new analytic methods for studying the disease families embraced by BioMed 21.


Develop new ways to address global health problems, including childhood malnutrition, obesity and antibiotic resistance

Discover new technologies for understanding how genetic variations impact health worldwide

Create innovative programs to prepare the next generation of scientists

Jeffrey Gordon, MD

Director: Jeffrey Gordon, MD

The University’s unique spirit of openness, cooperation and collaboration is the foundation for innovative interdisciplinary science, and allows faculty and their students to conduct groundbreaking science that will change the way medicine is practiced worldwide.

— Jeffrey Gordon, MD


Human health is affected not only by our own ‘human’ genes, but also by the millions of genes present in the tens of trillions of microbes that live on and in our bodies. The Center for Genome Sciences & Systems Biology (CGS_SB) was the first BioMed21 IRC to be established and serves as a model for future centers.

CGS_SB faculty and its cadre of inspiring PhD, MD/PhD and post-doctoral students are pioneering new ways to understand the complex circuitry that links our genes and their products together to shape our health and to determine our disease risks. Combining the biological, physical, computational and engineering sciences in unique ways, the CGS_SB is inventing new ways to characterize how our genetic differences and differing environmental exposures impact our well being. This effort includes new approaches for mining and interpreting the vast amounts of data generated by the revolutionary advances in the biomedical sciences.

Integral to its mission, the CGS_SB is also developing innovative new approaches for educating students to work at the interface between the biological and physical sciences so that they will be able to address the many pressing global health challenges we face this century.


Director: Jeffrey Gordon, MD, Dr. Robert J. Glaser Distinguished University Professor and professor of medicine, of developmental biology and of pathology and immunology